From San Francisco to San Francisco

With its myriad hills and spectacular bay, San Francisco beguiles with natural beauty, vibrant neighborhoods, and contagious energy. From the hipster Mission District to the sassy Castro, from bustling Union Square to enduring Chinatown, this dynamic town thrives on variety. The city makes it wonderfully easy to tap into the good life, too: between San Francisco's hot arts scene, tempting boutiques, parks perfect for jogging or biking, and all those stellar locavore restaurants and cocktail bars, it's the ultimate destination for relaxed self-indulgence.

Ketchikan is famous for its colorful totem poles, rainy skies, steep–as–San Francisco streets, and lush island setting. Some 13,500 people call the town home, and, in the summer, cruise ships crowd the shoreline, floatplanes depart noisily for Misty Fiords National Monument, and salmon-laden commercial fishing boats motor through Tongass Narrows. In the last decade Ketchikan's rowdy, blue-collar heritage of logging and fishing has been softened by the loss of many timber-industry jobs and the dramatic rise of cruise-ship tourism. With some effort, though, visitors can still glimpse the rugged frontier spirit that once permeated this hardscrabble cannery town. Art lovers should make a beeline for Ketchikan: the arts community here is very active. Travelers in search of the perfect piece of Alaska art will find an incredible range of pieces to choose from.The town is at the foot of 3,000-foot Deer Mountain, near the southeastern corner of Revillagigedo (locals shorten it to Revilla) Island. Prior to the arrival of white miners and fishermen in 1885, the Tlingit used the site at the mouth of Ketchikan Creek as a summer fish camp. Gold discoveries just before the turn of the 20th century brought more immigrants, and valuable timber and commercial fishing resources spurred new industries. By the 1930s the town bragged that it was the "salmon-canning capital of the world." You will still find some of Southeast's best salmon fishing around here. Ketchikan is the first bite of Alaska that many travelers taste. Despite its imposing backdrop, hillside homes, and many staircases, the town is relatively easy to walk through. Favorite downtown stops include the Spruce Mill Development shops and Creek Street. A bit farther away you'll find the Totem Heritage Center. Out of town (but included on most bus tours) are two longtime favorites: Totem Bight State Historical Park to the north and Saxman Totem Park to the south.

Juneau, Alaska's capital and third-largest city, is on the North American mainland but can't be reached by road. Bounded by steep mountains and water, the city’s geographic isolation and compact size make it much more akin to an island community such as Sitka than to other Alaskan urban centers, such as Fairbanks or Anchorage. Juneau is full of contrasts. Its dramatic hillside location and historic downtown buildings provide a frontier feeling, but the city's cosmopolitan nature comes through in fine museums, noteworthy restaurants, and a literate and outdoorsy populace. The finest of the museums, the Alaska State Museum, is scheduled to reopen in May 2016 on its old site as the expanded Alaska State Library, Archives, and Museum (SLAM) following several years of planning and exhibit research. Another new facility, the Walter Soboleff Center, offers visitors a chance to learn about the indigenous cultures of Southeast Alaska–-Tlingit, Haida, and Tsimshian. Other highlights include the Mt. Roberts Tramway, plenty of densely forested wilderness areas, quiet bays for sea kayaking, and even a famous drive-up glacier, Mendenhall Glacier. For goings-on, pick up the Juneau Empire (www.juneauempire.com), which keeps tabs on state politics, business, sports, and local news.

Located at the northern terminus of the Inside Passage, Skagway is a one-hour ferry ride from Haines. By road, however, the distance is 359 miles, as you have to take the Haines Highway up to Haines Junction, Yukon, then take the Alaska Highway 100 miles south to Whitehorse, and then drive a final 100 miles south on the Klondike Highway to Skagway. North-country folk call this sightseeing route the Golden Horseshoe or Golden Circle tour, because it passes a lot of gold-rush country in addition to spectacular lake, forest, and mountain scenery.The town is an amazingly preserved artifact from North America's biggest, most-storied gold rush. Most of the downtown district forms part of the Klondike Gold Rush National Historical Park, a unit of the National Park System dedicated to commemorating and interpreting the frenzied stampede of 1897 that extended to Dawson City in Canada's Yukon.Nearly all the historic sights are within a few blocks of the cruise-ship and ferry dock, allowing visitors to meander through the town's attractions at whatever pace they choose. Whether you're disembarking from a cruise ship, a ferry, or a dusty automobile fresh from the Golden Circle, you'll quickly discover that tourism is the lifeblood of this town. Unless you're visiting in winter or hiking into the backcountry on the Chilkoot Trail, you aren't likely to find a quiet Alaska experience around Skagway.

Just 40 mi (66 km) south of the Alaskan border, Prince Rupert is the largest community on British Columbia's north coast. Set on Kaien Island at the mouth of the Skeena River and surrounded by deep green fjords and coastal rain forest, Prince Rupert is rich in the culture of the Tsimshian, people who have been in the area for thousands of years. As the western terminus of Canada's second transcontinental railroad and blessed with a deep natural harbor, Prince Rupert was, at the time of its incorporation in 1910, poised to rival Vancouver as a center for trans-Pacific trade. This didn't happen, partly because the main visionary behind the scheme, Grand Trunk Pacific Railroad president Charles Hays, went down with the Titanic on his way back from a financing trip to England. Prince Rupert turned instead to fishing and forestry. A port of call for both BC and Alaska ferries, but relatively new to cruise ships, this community of 15,000 retains a laid-back, small-town air.

With its myriad hills and spectacular bay, San Francisco beguiles with natural beauty, vibrant neighborhoods, and contagious energy. From the hipster Mission District to the sassy Castro, from bustling Union Square to enduring Chinatown, this dynamic town thrives on variety. The city makes it wonderfully easy to tap into the good life, too: between San Francisco's hot arts scene, tempting boutiques, parks perfect for jogging or biking, and all those stellar locavore restaurants and cocktail bars, it's the ultimate destination for relaxed self-indulgence.